Our Experience with Stem Cell Applications in Patients with Advanced Peripheral Arterial Disease
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Abstract
Objective: To assess the results of stem cell applications in patients with peripheral
arterial disease who could not undergo surgical treatment due to advanced-stage
ischemia.
Study design: Patients who could not undergo revascularization due to distal
vascular insuffi ciency were recruited into this study between June 2009 and 2015.
Stem cells obtained via bone marrow aspiration were utilized in 30 patients (17 male,
13 female; mean age, 56.2 y), and stem cells obtained from abdominal fat tissue were
utilized in another 30 patients (22 male, 8 female; mean age, 58.9 y). Twenty patients
with similar clinical symptoms who received medical treatment only comprised the
control group for comparisons.
Results: Stem cells were harvested from the bone marrow under local anesthesia,
while general anesthesia was used for collecting stem cells of adipose tissue origin.
Cells collected from each patient were processed in mobile units and were ready
to use within approximately 1 hour. The harvested stem cells were administered
percutaneously via intramuscular injections into the target tissues, conforming to
vascular anatomy. Clinical status, ankle-brachial indices, pulse oximetry, and walking
distance with exercise test were assessed at 1, 3, and 6 months after the procedures.
Conclusion: Stem cell applications performed in patients unfeasible for
revascularization appear to be associated with improvements in clinical symptoms,
quality of life, and walking distance. We believe that this therapy may help reduce the
rate of amputation
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Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG, et al. Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). J Vasc Surg. 2007;45 Suppl S:S5-67. Available from: https://doi.org/10.1016/j.jvs.2006.12.037
Dormandy JA, Rutherford RB. Management of peripheral artery disease. Tasc Working Group, Transatlantic Inter-Society Consensus. J Vasc Surg. 2000;31(1 Pt 2):S1-S296.
Şahin F, Saydam G, Omay SB. Kök Hücre Plastisitesi ve Klinik Pratikte Kök Hücre Tedavisi [Stem Cell Plasticity and Stem Cell Therapy in Clinical Practice]. Turkish Journal of Hematology and Oncology. 2005;1:48-56. Available from: https://search.trdizin.gov.tr/en/yayin/detay/46532
Durdu S, Akar AR, Arat M, Sancak T, Eren NT, Ozyurda U. Autologous bone marrow mononuclear cell implantation for patients with Rutherford grade II–III thromboangiitis obliterans. J Vasc Surg. 2006;44:732–9. Available from: https://doi.org/10.1016/j.jvs.2006.06.023
Esato K, Hamano K, Li TS, Furutani A, Seyama A, Takenaka H, Zempo N. Neovascularization induced by autologous bone marrow cell implantation in peripheral arterial disease. Cell Transplant. 2002;11:747–52. Available from: https://pubmed.ncbi.nlm.nih.gov/12588106/
Silvestre JS, Gojova A, Brun V, Potteaux S, Esposito B, Duriez M, et al. Transplantation of bone marrow-derived mononuclear cells in ischemic apolipoprotein E-knockout mice accelerates atherosclerosis without altering plaque composition. Circulation. 2003;108:2839–42. Available from: https://doi.org/10.1161/01.CIR.0000106161.43954.DF
Amann B, Luedemann C, Ratei R, Schmidt-Lucke JA. Autologous Bone Marrow Cell Transplantation Increases Leg Perfusion and Reduces Amputations in Patients With Advanced Critical Limb Ischemia Due to Peripheral Artery Disease. Cell Transplant. 2009;18:371–80. Available from: https://doi.org/10.3727/096368909788534942
Ito WD, Arras M, Winkler B, Scholz D, Schaper J, Schaper W. Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusion. Circ Res. 1997;80:829–37. Available from: https://doi.org/10.1161/01.RES.80.6.829
Uhank L, Sheridan KM, Dalsig MC. Collateral growth in the peripheral circulation: A review. Vasc Endovas Surg. 2003;38:291-313. Available from: https://www.proquest.com/docview/198723065?sourcetype=Scholarly%20Journals
Fadini GP, Agostini C, Avogaro A. Autologous stem cell therapy for peripheral arterial disease meta-analysis and systematic review of the literature. Atherosclerosis. 2010;209(1):10-7. Available from: https://doi.org/10.1016/j.atherosclerosis.2009.08.033