Abstract

Research Article

The pattern of blood pressure and renal function among children with Sickle Cell Anaemia presenting in a tertiary health institution in Nigeria

Adebukola Ajite*, Ezra Ogundare, Oludare Oluwayemi, Oladele Olatunya, Oluwasola Oke, Kayode Tolorunju and Evelyn Omoniyi

Published: 16 April, 2019 | Volume 3 - Issue 1 | Pages: 083-092

Background: In sickle cell anemia (SCA), compromise of the renal vasculature due to sickled red cells has been recognized.

Objectives: To assess the renal function and blood pressure pattern in children with sickle cell anaemia (SCA) presenting in a tertiary institution.

Method: A cross-sectional study of patients with sickle cell anaemia (SCA) over six months involving the use of questionnaires, general physical examination, blood pressure, investigations for haemoglobin genotype, urinalysis, serum creatinine, screening for hepatitis B and HIV.

Results: 51 children with SCA were seen. The prevalence of impaired renal function as defined by reduced eGFR <90mL/min/1.73m2 in this study was 27.5%, previous hospital admission and blood transfusion were associated with reduction in eGFR but blood pressure did not have significant correlation with the eGFR. The overall mean age at diagnosis of SCA was 4.09 ± 3.33 (years).

Conclusion: Impaired renal function is a major comorbid condition in children with SCA. In countries/locations where there is no newborn screening for sickle cell disease, diagnosis is delayed, thus detecting impaired renal function may be delayed, therefore the need for early detection and management is imperative.
Introduction

Read Full Article HTML DOI: 10.29328/journal.jcn.1001031 Cite this Article Read Full Article PDF

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