Research Article

Chronic Kidney Disease: A single day screening on World Kidney Day for five consecutive years

Rai Pradeep K*, Rai Punam and Bedi Sonam

Published: 12 March, 2019 | Volume 3 - Issue 1 | Pages: 046-054

Introduction: Chronic kidney disease is a costly and burdensome public health concern. Delayed recognition and treatment of CKD may predispose patients to unfavorable future outcomes and burden the healthcare services. The early detection of disease via screening programs is widely recommended. The present study is a hospital camp-based screening for detecting patients with chronic kidney disease in Varanasi from 2014-18.

Methods: The study subjects constituted 436 apparently healthy adults (age ≥18 years) of Varanasi. Information on socio-demographic profile, personal characteristics and clinical investigations were recorded. Stepwise binary logistic regression analysis was applied to find the significant predictors of chronic kidney disease.

Results: Median age of the study subjects was 40.5 years. There were 39.7% males and 60.3% females. Chronic kidney disease was found in 23.9% subjects. Underweight, diabetes mellitus, hypertension, smoking status and higher creatinine levels came out as significant predictors of chronic kidney disease.

Conclusion: We screened apparently healthy individuals and found very high percentages of chronic kidney disease and its predictors. Henceforth, understanding the preventable and modifiable risk factors of chronic kidney disease becomes a prerequisite to intervene before risk populations reaches to irreversible stages of adverse future outcomes.

Read Full Article HTML DOI: 10.29328/journal.jcn.1001025 Cite this Article Read Full Article PDF


Chronic kidney disease; Serum creatinine; Albuminuria; Hypertension; Diabetes mellitus; Smoking


  1. Everett B, Castel LD, McGinnis M, Beresky A, Cane RC Jr, et al. Economic and Clinical Outcomes Resulting From the Stage 4 Chronic Kidney Disease Case Management Quality Improvement Initiative. Prof Case Manag. 2017; 22: 291. Ref.: https://goo.gl/joWb7W
  2. Ojo A. Addressing the Global Burden of Chronic Kidney Disease through Clinical and Translational Research. Trans Am Clin Climatol Assoc. 2014; 125: 229-243. Ref.: https://goo.gl/6DzNKh
  3. Mendelssohn DC. Coping with the CKD Epidemic: The Promise of Multidisciplinary Team-Based Care. Nephrol Dial Transplant. 2005; 20: 10–12. Ref.: https://goo.gl/W3r8bm
  4. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, et al. A More Accurate Method to Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation. Ann Intern Med. 1999; 130: 461–70. Ref.: https://goo.gl/MdkXrh
  5. Ulasi II, Ijoma CK, Onodugo OD, Arodiwe EB, Ifebunandu NA, et al. 2013. Towards Prevention of Chronic Kidney Disease in Nigeria: A Community-Based Study in Southeast Nigeria. Kidney International Supplements. 2017; 3: 195–201. Ref.: https://goo.gl/CRpz9b
  6. Ketteler M, Block GA, Evenepoel P, Fukagawa M, Herzog CA, et al. Executive Summary of the 2017 KDIGO Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) Guideline Update: What’s Changed and Why It Matters. Kidney Int. 2017; 92: 26–36. Ref.: https://goo.gl/RfKNHH
  7. Neuen BL, Chadban SJ, Demaio AR, Johnson DW, Perkovic V. Chronic Kidney Disease and the Global NCDs Agenda. BMJ Glob Health. 2017; 2: e000380. Ref.: https://goo.gl/z3ZfYW
  8. Wang H, Naghavi M, Allen C, Barber RM, Bhutta ZA, et al. Global, Regional, and National Life Expectancy, All-Cause Mortality, and Cause-Specific Mortality for 249 Causes of Death, 1980–2015: A Systematic Analysis for the Global Burden of Disease Study 2015. The Lancet. 2016; 388: 1459–1544. Ref.: https://goo.gl/86Yu6C
  9. Agarwal SK, Dash SC, Irshad M, Raju S, Singh R, et al. Prevalence of Chronic Renal Failure in Adults in Delhi, India. Nephrol Dial Transplant. 2005; 20: 1638–1642. Ref.: https://goo.gl/zkKD9D
  10. Haroun MK, Jaar BG, Hoffman SC, Comstock GW, Klag MJ, et al. Risk Factors for Chronic Kidney Disease: A Prospective Study of 23,534 Men and Women in Washington County, Maryland. J Am Soc Nephrol. 2003; 14: 2934–2941. Ref.: https://goo.gl/hc9Qbd
  11. Ležaić V, Bajčetić S, Peruničić-Peković G, Bukvić D, Dimković N, et al. Screening of Elderly for Chronic Kidney Disease. Kidney Blood Press Res. 2012; 35: 497–503. Ref.: https://goo.gl/FqrKTX
  12. Modi GKVM, Jha V. The Incidence of End-Stage Renal Disease in India: A Population-Based Study. Kidney int. 2006; 70: 2131–2133. Ref.: https://goo.gl/bMGC4K
  13. Rai PK, Rai P, Bedi S. Prevalence and Risk Factors of Chronic Kidney Disease: A Single Day Screening on World Kidney Day for Four Consecutive Years in Varanasi. Urology & Nephrology Open Access Journal. 2018; 6: 167–171. Ref.: https://goo.gl/3TqPQe
  14. Rai PK, Jindal PK, Rai P, Rai PK, Rai SN, et al. Screening of Chronic Kidney Disease (CKD) in General Population on World Kidney Day on Three Consecutive Years: A Single Day Data. Int J Med Public health. 2014; 4: 167-170. Ref.: https://goo.gl/8ixfzs
  15. Singh AK, Farag YM, Mittal BV, Subramanian KK, Reddy SR, et al. Epidemiology and Risk Factors of Chronic Kidney Disease in India–results from the SEEK (Screening and Early Evaluation of Kidney Disease) Study. BMC nephrology. 2013; 14: 114. Ref.: https://goo.gl/Q3WhJ4
  16. Hill NR, Fatoba ST, Oke JL, Hirst JA, O'Callaghan CA, et al. Global Prevalence of Chronic Kidney Disease–a Systematic Review and Meta-Analysis. PloS One. 2016; 11: e0158765. Ref.: https://goo.gl/7ph4Jy
  17. Varma PP. Prevalence of Chronic Kidney Disease in India-Where Are We Heading? Indian J Nephrol. 2015; 25: 133-135. Ref.: https://goo.gl/fwdfDs
  18. Levey AS, Eckardt KU, Tsukamoto Y, Levin A, Coresh J, et al. Definition and Classification of Chronic Kidney Disease: A Position Statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 2005; 67: 2089–2100. Ref.: https://goo.gl/HEvXdc
  19. Sherwood M, McCullough PA. Chronic Kidney Disease from Screening, Detection, and Awareness, to Prevention. Lancet Glob Health. 2016; 4: e288–289. Ref.: https://goo.gl/tr7TU2
  20. WebsterAC, Nagler EV, Morton RL, Masson P. Chronic Kidney Disease. The Lancet. 2017; 389(10075): 1238–1252. Ref.: https://goo.gl/b8225L
  21. KazancioğluR. Risk Factors for Chronic Kidney Disease: An Update. Kidney Int Suppl. 2013; 3: 368–371. Ref.: https://goo.gl/2dMuVf
  22. Yacoub R, Habib H, Lahdo A, Al Ali R, Varjabedian L, et al. Association between Smoking and Chronic Kidney Disease: A Case Control Study. BMC Public Health. 2010; 10: 731. Ref.: https://goo.gl/Ca8KPU
  23. Orth SR. Smoking and the Kidney. JASN. 2002; 13: 1663–1672. Ref.: https://goo.gl/bDTt93
  24. Baumgarten M, Gehr T. Chronic Kidney Disease: Detection and Evaluation. American Family Physician. 2011; 84: 1138-1148. Ref.: https://goo.gl/BgUr8M
  25. Woodhouse S, Batten W, Hendrick H, Malek PA. The Glomerular Filtration Rate: An Important Test for Diagnosis, Staging, and Treatment of Chronic Kidney Disease. Laboratory Medicine. 2015; 37: 244–246. Ref.: https://goo.gl/38aakC
  26. Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS. Prevalence of Chronic Kidney Disease and Decreased Kidney Function in the Adult US Population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis. 2003; 41: 1–12. Ref.: https://goo.gl/nJ5a4K
  27. Lindeman RD, Tobin J, Shock NW. Longitudinal Studies on the Rate of Decline in Renal Function with Age. J Am Geriatr Soc. 1985; 33: 278–285. Ref.: https://goo.gl/nyo1nN
  28. Turin TC, James M, Ravani P, Tonelli M, Manns BJ, et al. Proteinuria and Rate of Change in Kidney Function in a Community-Based Population. J Am Soc Nephrol. 2013; 24: 1661-1667. Ref.: https://goo.gl/SKBQ1B
  29. Pounds LL, Teodorescu VJ. Chronic Kidney Disease and Dialysis Access in Women. J Vasc Surg. 2013; 57: 49S–53S. Ref.: https://goo.gl/uQX5nw
  30. Kovesdy CP, Anderson JE, Kalantar-Zadeh K. Paradoxical Association between Body Mass Index and Mortality in Men with CKD Not yet on Dialysis. Am J Kidney Dis. 2007; 49: 581–591. Ref.: https://goo.gl/VJs2he
  31. Fouad M, Ismail MI, Gaballah A, E Reyad, ELdeeb S. Prevalence of Obesity and Risk of Chronic Kidney Disease among Young Adults in Egypt. Indian J Nephrol. 2016; 26: 413-418. Ref.: https://goo.gl/tbWnHM
  32. Kovesdy CP, Furth SL, Zoccali C, World Kidney Day Steering Committee. Obesity and Kidney Disease: Hidden Consequences of the Epidemic. Nephron. 2017; 135: 243–251. Ref.: https://goo.gl/EZUuUf
  33. Mallamaci F, Tripepi G. Obesity and CKD Progression: Hard Facts on Fat CKD Patients. Nephrol Dial Transplant. 28(suppl_4): iv105-iv108. Ref.: https://goo.gl/xZoANq
  34. Blüher M. Are There Still Healthy Obese Patients? Current Opinion in Endocrinology. Diabetes and Obesity. 2012; 19: 341–346. Ref.: https://goo.gl/ckbz1z
  35. Lopez-Giacoman S, Madero M. Biomarkers in Chronic Kidney Disease, from Kidney Function to Kidney Damage. World J Nephrol. 2015; 4: 57-73. Ref.: https://goo.gl/8z183s
  36. Abcar AC, Chan L, Yeoh H. What To Do for the Patient with Minimally Elevated Creatinine Level? Perm J. 2004; 8: 51-53. Ref.: https://goo.gl/1CE9v3
  37. Lin CC, Li CI, Liu CS, Lin WY, Lin CH, et al. Development and Validation of a Risk Prediction Model for End-Stage Renal Disease in Patients with Type 2 Diabetes. Sci Rep. 2017; 7: 10177. Ref.: https://goo.gl/MxtHcN
  38. Veerappan I, Abraham G. Chronic Kidney Disease: Current Status, Challenges and Management in India. Ch. 2013; 130: 593–597. Ref.: https://goo.gl/D763yt
  39. Weiner DE, Tighiouart H, Amin MG, Stark PC, MacLeod B, et al. Chronic Kidney Disease as a Risk Factor for Cardiovascular Disease and All-Cause Mortality: A Pooled Analysis of Community-Based Studies. J Am Soc Nephrol. 2004; 15: 1307–1315. Ref.: https://goo.gl/KkEj5z

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