Short Communication

Cardiac Manifestations on Anti-Phospholipid Syndrome

Faisal AH*

Published: 23 March, 2017 | Volume 1 - Issue 1 | Pages: 011-013

Antiphospholipid syndrome may present in various ways from cutaneous manifestation, obstetric complications, neurological manifestation, and cardiac manifestation to renal involvement. There are many cardiac complication of anti-phospholipid syndrome, among them are valvular dysfunction, pulmonary hypertension, myocardial infarction, intracardiac thrombi, and ventricular dysfunction [1]. The most common cardiac manifestation is valvular abnormalities ranging from 11.6-32% [2-5].

Read Full Article HTML DOI: 10.29328/journal.jcn.1001002 Cite this Article Read Full Article PDF


  1. F Tenedios, D Erkan, MD Lockshin. Cardiac involvement in the Antiphospholipid Syndrome. Lupus. 2005; 14: 691-696. Ref.: https://goo.gl/WduHgp
  2. Asherson RA, Khamashta MA, Ordi-Ros J, Derksen RH, Machin SJ, et al. The primary antiphospholipid syndrome: Major clinical and serological features. Medicine (Baltimore). 1989; 68: 366-734. Ref.: https://goo.gl/4ezdoF
  3. Leventhal JL, Borofsky MA, Bergey PD, Schumacher HR. Antiphospholipid antibody syndrome with right atrial thrombosis mimicking an atrial myxoma. Am J Med. 1989; 87: 111-113. Ref.: https://goo.gl/6OfofH
  4. Gertner E, Leatherman JW. Intracardiac mural thrombus mimicking atrial myxoma in the antiphospholipid syndrome. J Rheumatol. 1992; 19: 1293-1298. Ref.: https://goo.gl/zTe5DU
  5. Love PE, Santoro SA. Antiphospholipid antibodies: Anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and on non-SLE disorders. Ann Intern Med. 1990; 112: 682-698. Ref.: https://goo.gl/i4JSGO
  6. Julio AA, Carmen S. Intracardiac thrombus in antiphospholipid antibody syndrome. J Am Soc Echocardiogr. 2000; 13: 873-875. Ref.: https://goo.gl/Ih4SGK
  7. Coppock MA, Safford RE, Danielson GK. Intracardiac thrombosis, phospholipid antibodies, and two-chambered right ventricle. Br Heart J. 1988; 60: 455-458. Ref.: https://goo.gl/RgLSQ3
  8. Kaplan SD, Chartash EK, Pizzarello RA, Furie RA. Cardiac manifestations of the antiphospholipid syndrome. Am Heart J. 1992; 124: 1331-1338. Ref.: https://goo.gl/dHgKls
  9. Rosove MH, Brewer PM. Antiphospholipid thrombosis: Clinical course after the first thrombotic event in 70 patients. Ann Intern Med. 1992; 117: 303-308. Ref.: https://goo.gl/lFk1sF
  10. Asherson RA, Cervera R. Antiphospholipid antibodies and the heart. Lessons and pitfalls for the cardiologist. Circulation. 1991; 84: 920-923. Ref.: https://goo.gl/cn9W7F
  11. Mohammed AG, Alghamdi AA, ALjahlan MA, Al-Homood IA. Echocardiographic findings in asymptomatic systemic lupus erythematosus patients. Clin Rheumatol. 2017; 36: 563. Ref.: https://goo.gl/RwEjIo
  12. Kotkar KD, Said SM. Libman-Sacks Endocarditis in a Patient With Antiphospholipid Syndrome. Ann Thorac Surg. 2016; 102: e31-e32. Ref.: https://goo.gl/0LDy9Z
  13. Adler Y, Finkelstein Y, Zandeman-Goddard G, Blank M, Lorber M, et al. The presence of antiphospholipid antibodies in acute myocardial infarction. Lupus. 1995; 4: 309-313. Ref.: https://goo.gl/wy1i6g
  14. Prashanth P, Mukhaini M, Riyami A. A rare presentation of Primary Antiphospholipid Syndrome. Oman Med J. 2009; 24: 300-302. Ref.: https://goo.gl/ta6tkt
  15. Leung WH, Wong KL, Lau CP, Wong CK, Cheng CH. Association between antiphospholipid antibodies and cardiac abnormalities in patients with systemic lupus erythematosus. Am J Med. 1990; 89: 411-419. Ref.: https://goo.gl/Ne21eb
  16. Lockshin M, Tenedios F, Petri M, McCarty G, Forastiero R, et al. Cardiac disease in the antiphospholipid syndrome. Lupus. 2003; 12: 518-523. Ref.: https://goo.gl/lLC2d0
  17. Molad Y, Gorshtein A, Wysenbeek AJ, Guedj D, Majadla R, et al. Protective effect of hydroxychloroquine in systemic lupus erythematosus. Prospective long-term study of an Israeli cohort. Lupus. 2002; 11: 356-361. Ref.: https://goo.gl/8JBBh5
  18. G Finazzi, R Marchiolli, Brancaccio V, Schinco P, Wisloff F, et al. A Randomized clinical trial done comparing high intensity warfarin vs. conventional antithrombotic therapy for the prevention of recurrent thrombosis in patients with antiphospholipid syndrome (WAPS). J Thromb Haemost. 2005; 3: 848-853. Ref.: https://goo.gl/dT9qke
  19. Espinosa G, Cervera R. Current treatment of antiphospholipid syndrome: lights and shadows. Nat Rev Rheumatol. 2015; 11: 586-596. Ref.: https://goo.gl/0FNsF5

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?