Figure 9

An update on the approaches of avoidance of propagation of chronic kidney disease resulting in reversal or possible need or avoidance of kidney transplantation - a systematic review

Kulvinder Kochar Kaur*, Gautam Allahbadia and Mandeep Singh

Published: 10 May, 2022 | Volume 6 - Issue 2 | Pages: 040-057

jcn-aid1089-g009

Figure 9:

Courtesy ref no-6-The numerousmodes of metabolic acidosis on renal propagation like escalation of, ammonia generation in nephrons that escaped damage from complement activationbesides enhancement of endothelin generation, resulting in reduction in GFR and enhancement  of tubulointerstitialdamage. Escalation of ammonia generation, in the nephrons that are surviving might cause activation of complement correlated with tubulointerstitial injury [101]. Enhancement of endothelin generation associated with metabolic acidosis is observed to cause, reduction of GFR along with tubulointerstitial damage. More than the renal side actions, metabolic acidosis negatively impacts the cardiovascular outcomes (CVOT) through exaggeration of inflammatory reaction, escalation of aldosterone development, enhancement of  endothelin generation besides dysregulation of endothelial function, besides reduction in Na+/K+ ATPase action as well as followed by dyregulation of cardiac contractility [103]. Furthermore, metabolic acidosis is correlated with dysregulation of bone mineralization, IR, along with, greater all cause mortality. See text for details. 

Read Full Article HTML DOI: 10.29328/journal.jcn.1001089 Cite this Article Read Full Article PDF

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