Figure 9

Collecting duct PGE2 responses reduce water loss with empagliflozin in mice with type 2 diabetes mellitus

R Nasrallah, J Zimpelmann, V Cheff, JF Thibodeau, KD Burns and RL Hébert*

Published: 08 April, 2021 | Volume 5 - Issue 1 | Pages: 023-030

jcn-aid1069-g009

Figure 9:

Water transport in microdissected IMCD. Net fluid reabsorption (Jv) was analyzed in 4 mouse groups: control (db/m), db/m+EMPA, diabetic (db/db), and db/db+EMPA. IMCD were microdissected and Jv (nl/mm/min) was determined. Tubules were stimulated with 10-12M AVP followed by AVP+10-7M PGE2. In A) a representative tracing of each group is shown. In B) Jv is shown as mean+/-SEM, white bars for AVP alone and black bars for AVP+PGE2. *p < 0.05 vs. AVP, and significance between groups is indicated with a black line.

Read Full Article HTML DOI: 10.29328/journal.jcn.1001069 Cite this Article Read Full Article PDF

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