Figure 1

SGLT2 Inhibitors and nephroprotection in diabetic kidney disease: From mechanisms of action to the latest evidence in the literature

Jorge Rico-Fontalvo, Rodrigo Daza-Arnedo, Maria Ximena Cardona-Blanco, Victor Leal-Martínez, Emilio Abuabara-Franco, Nehomar Pajaro-Galvis*, Jose Cabrales, José Correa, Manuel Cueto, Amable Duran, Alejandro Castellanos, Javier Enamorado, José Bohórquez, Isabella Uparella, Julio Zuñiga, Abraham Chagui, Alfonso Ramos and Luis Lara

Published: 21 August, 2020 | Volume 4 - Issue 2 | Pages: 044-055

jcn-aid1058-g001

Figure 1:

Normal nephron. The reabsorption of glucose is produced through the co-transporters SGL T1 and SGLT2, expressed in the apical membrane of the proximal tubule. SGLT2 reabsorbs approximately around 80% to 90% of the filtered glucose. The resting 10% to 20% is reabsorbed by SGLT1, a high affinity and low capacity transporter that is expressed in the apical membrane of the epithelium in the proximal descending tubule.

Read Full Article HTML DOI: 10.29328/journal.jcn.1001058 Cite this Article Read Full Article PDF

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