Abstract

Case Report

Hypocomplementemic interstitial nephritis with long-term follow-up

Alyssa Penning, M.D, Claire Kassakian, M.D, Donald C Houghton, M.D, Nicole K Andeen and M.D*

Published: 22 February, 2019 | Volume 3 - Issue 1 | Pages: 042-045

Prednisone-sensitive hypocomplementemia, renal insufficiency, and kidney biopsy demonstrating severe tubulointerstitial nephritis (TIN), storiform fibrosis, and tubulointerstitial immune deposits are typical of IgG4-related tubulointerstitial nephritis and hypocomplementemic interstitial nephritis. A diagnosis of hypocomplementemic interstitial nephritis requires clinical and pathologic exclusion of IgG4-related tubulointerstitial nephritis. We describe a patient with hypocomplementemic interstitial nephritis who did not develop diagnostic features of IgG4 related disease (RD) over 2-year follow-up. We conclude that hypocomplementemic interstitial nephritis could be on a biologic spectrum with IgG4-related disease, but not all cases will develop the abundance of IgG4-positive plasma cells, systemic manifestations, or elevated immunoglobulin levels characteristic of IgG4-RD.

Read Full Article HTML DOI: 10.29328/journal.jcn.1001024 Cite this Article Read Full Article PDF

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