Abstract

Case Report

Complete recovery of chronic Osmotic Demyelination Syndrome with plasma exchange

Sumbal Nasir Mahmood*, Kunwer Naveed Mukhtar, Osama Kunwer Naveed and Ahmed Kunwer Naveed

Published: 08 March, 2018 | Volume 2 - Issue 1 | Pages: 005-007

A 50-years old female presented with dysarthria, inability to swallow and quadriparesis for three weeks. She had rapid correction of her serum sodium (Na) from 99meq/l to 138meq/l within 24 hours 1 week prior to development of these symptoms. She was diagnosed as a case of Osmotic demyelination syndrome (ODS) formerly known as central pontine myelinolysis (CPM) which was confirmed by MRI. She underwent Plasma Exchange (PE) on the 20th day since her symptoms started and underwent 7 cycles of PE with complete neurological recovery. Pt was discharged with ability to ambulate independently and complete recovery of speech and swallowing. Hence, we report that PE is beneficial in chronic ODS.

Read Full Article HTML DOI: 10.29328/journal.jcn.1001011 Cite this Article Read Full Article PDF

Keywords:

Hyponatremia; Osmotic demyelination syndrome; Plasma exchange

References

  1. Gankam Kengne F, Soupart A, Pochet R, Brion JP, Decaux G. Reinduction of hyponatremia after rapid overcorrection of hyponatremia reduces mortality in rats. Kidney Int. 2009; 76: 614-621. Ref.: https://goo.gl/PKiHd9
  2. Yamada H, Takano K, Ayuzawa N, Seki G, Fujita T. Relowering of serum Na for osmotic demyelinating syndrome. Case Rep Neurol Med. 2012. Ref.: https://goo.gl/z8LR7n
  3. Chang KY, Lee IH, Kim GJ, Cho K, Park HS, et al. Plasma exchange successfully treats central pontine myelinolysis after acute hypernatremia from intravenous sodium bicarbonate therapy. BMC Nephrol. 2014; 15: 56. Ref.: https://goo.gl/ukH27g
  4. King JD, Rosner MH. Osmotic Demyelination syndrome. Am J Med Sci. 2010; 339: 561-567. Ref.: https://goo.gl/aqpUEZ
  5. Murthy SB, Izadyar S, Dhamne M, Kass JS, Goldsmith CE. Osmotic demyelination syndrome: variable clinical and radiologic response to intravenous immunoglobulin therapy. Neurol Sci. 2013; 4: 581-584. Ref.: https://goo.gl/TepmcX
  6. Sardar GK, Eilbert WP. Severe hyponatremia associated with thiazide diuretic use. J Emerg Med. 2015; 48: 305-309. Ref.: https://goo.gl/ZLLjTA
  7. Koller H, Kieseier BC, Jander S, Hartung HP. Chronic inflammatory demyelinating neuropathy. N Engl J Med. 2005; 352: 1343-1356. Ref.: https://goo.gl/MN8xN8
  8. Louis G, Megarbane B, Lavoue S, Lassalle V, Argaud L, et al. Long term outcome of patients hospitalized in intensive care units with central or extrapontine myelinolysis. Crit Care Med. 2012; 40: 970-972. Ref.: https://goo.gl/5JRo4Z
  9. Kumon S, Usui R, Kuzuhara S, Nitta K, Koike M. The improvement of the outcome of osmotic demyelination syndrome by Plasma exchange. Intern Med. 2017; 56: 733-736. Ref.: https://goo.gl/1zgNYY

Figures:

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