Abstract

Research Article

Association between bh4/bh2 ratio and Albuminuria in Hypertensive Type -2 Diabetic patients

Jose Aviles-Herrera, Karla C Arana-Pazos, Leonardo Del Valle-Mondragon, Carolina Guerrero-García and Alberto Francisco Rubio-Guerra*

Published: 29 December, 2017 | Volume 1 - Issue 1 | Pages: 060-063

Endothelial dysfunction and inflammation play a key role in the pathophysiology of diabetic nephropathy; Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide synthase, when BH4 is reduced to dihydrobiopterin (BH2), endothelial dysfunction is induced.

Purpose: The aim of this study is to evaluate the relationship between the levels of biopterins with albuminuria in type-2 diabetic hypertensive patients.

Methods: We studied 30 hypertensive type-2 diabetic patients in whom biopterins levels were measured by reverse phase high performance liquid chromatography with fluorescence detection. Additionally, 24 h urinary albumin excretion was also measured (nephelometry). The levels of biopterins and albuminuria were correlated with the Pearson correlation coefficient.

Results: We did not find a significantly correlation between biopterins levels and albuminuria, However, we found a significantly inverse correlation (R= -0.498, p<0.005) between the BH4/BH2 ratio and albuminuria.

Conclusion: Our results suggest that the BH4/BH2 ratio instead of biopterins levels may be a marker of nephropathy in hypertensive type-2 diabetic patients.

Read Full Article HTML DOI: 10.29328/journal.jcn.1001009 Cite this Article Read Full Article PDF

Keywords:

Tetrahydrobiopterin; Dihydrobiopterin; BH4/BH2 ratio; Albuminuria; Endothelial dysfunction

References

  1. Walker JD. An update on diabetic renal disease. Br J Diabetes Vasc Dis. 2010; 10: 219-223. Ref.: https://goo.gl/tuKN34
  2. Rubio AF, Vargas H, Lozano JJ, Escalante BA. Corrrelation between circulating adhesión molecules levels and albuminuria in type 2 diabetic hypertensive patients. Kydney Blood Press Res. 2009; 32: 106-109. Ref.: https://goo.gl/Hez4TN
  3. Rubio-Guerra AF, Vargas-Robles H. Ramos-Brizuela LM. Escalante-Acosta BA. Is tetrahydrobiopterin a therapeutic option in diabetic hypertensive patients? Integr Blood Press Control. 2010; 3: 125-132. Ref.: https://goo.gl/zwyA7u
  4. Takeda M, Yamashita T, Shinohara M, Sasaki N, Takaya T. Nakajima K et al. Plasma tetrahydrobiopterin/dihydrobiopterin ratio. A posible marker of endothelial dysfunction. Cir J. 2009; 955-962. Ref.: https://goo.gl/osbbAE
  5. Bauersachs J, Widder JD. Tetrahydrobiopterin, endothelial nitric oxide synthase, and mitochondrial function in the heart. Hypertension. 2009; 53: 907-908. Ref.: https://goo.gl/CCUCjF
  6. ChanWB, Chan NN, Lai CW, So WY, Lo MK, et al. Vascular defect beyond the endothelium in type II diabetic patients with overt nephropathy and moderate renal insufficiency. Kidney International. 2006; 70: 711-716. Ref.: https://goo.gl/YhMdFA
  7. Lim SC, Logerfo FW, Caballero AE, Horton ES, Smakowski P, et al. Soluble intercellular molecule, vascular C adhesion molecule, and impaired microvascular reactivity are early markers of vasculopathy in type 2 diabetic individuals without microalbuminuria. Diabetes care. 1999; 22: 1865-1870. Ref.: https://goo.gl/P35yJp
  8. Taslipinar A, Yaman H, Ilker M, Demirbas S, Saglam M, et al. The relationship between inflammation, endothelial dysfunction and proteinuria in patients with diabetic nephropathy. Scan J Clin & Lab Invest. 2011; 71: 606-612. Ref.: https://goo.gl/bwMGrD
  9. Rubio-Guerra AF, Vargas-Robles H, Del Valle-Mondragon L, Lozano-Nuevo JJ, Escalante-Acosta BA. Association between the levels of circulating adhesion molecules and biopterins in type-2 diabetic normotensive patients adhesion molecules and biopterins. Endocr Metab Immune Disord Drug Targets. 2012; 12: 243-246. Ref.: https://goo.gl/5FDzXL

Figures:

Figure 1

Figure 1

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More